Profile

About my work
I’ve always found living things fascinating, so after school I did a genetics degree and went on from there. The most interesting things of all to me were “jumping genes” or “transposons”: genes that break the rules! 
Transposons were discovered by my science hero, Barbara McClintock, in the 1950s. Hardly anyone understood her at first because they’re so weird: instead of staying put in an animal’s (or plant’s) chromosome and getting passed on to its offspring like normal genes, transposons move around and multiply. It turns out they’re extremely common and very important – more than half of human DNA is either transposons, or the remains of ancient transposons! Transposons can cause genetic disease, but they can also speed up evolution. You can even use them as tools for genetic engineering.

This is Barbara McClintock winning the Nobel Prize in 1983. She showed’em.
Most of my work has been on transposons and “whose side they’re on” – should we think of them as DNA diseases, or as helpers?  But like most people (!) I’m also interested in sex. I’ve worked out how often wild yeast have sex, and why a bodysnatching flower fungus prefers to have sex with itself. I use a lot of maths in my work. It’s not that bad. Really.

Yeast cells doin’it. The pear-shaped cells are growing towards attractive partners – when they touch, they mate.
As for me – I’m 33, live in Reading with my boyfriend and two cats, I’m training for a half marathon and I like baking cakes. I named one of our cats Morgan after a scientist, but my boyfriend wouldn’t let me call the other one Theodosius Dobzhansky.

Morgan and Trouble. Because cute pictures of cats are what the internet is all about.

It depends on the day, but here’s what I did today:
I spent the morning working on a paper which I’ve been writing with some colleagues from Queen Mary University in London. It’s about a strange quirk of our genes, which is that there’s only one way to stay “start making protein!” but three ways to say “stop!” (That’s as simply as I can say it, but do ask me for more explanation!). Nobody knows why. We have an idea which we’ve tested in as many ways as we can think of, and now we’re trying to get a paper published. I’m rewriting the bits of it that were difficult to understand, or that people disagreed about, in the first version.

Reading Uni has rather a pretty campus, so I often take my lunch outside for a picnic in the botanic garden.
After lunch I  had a meeting with the two students who are doing research projects with me next year. Both of them will be learning computer programming for the first time! One, Emma, is going to be researching the evolution of ageing in computer-simulated life forms, and the other, Nathan, will be looking at a weird seaweed that reads its DNA in a different way to anything else on earth.
Then for the boring bit – I had loads of marking to do, because it’s exam time. I enjoy teaching, but I’m not a “natural” and have only been doing it for a couple of years. So it’s been difficult at times… both for me and my students!

My office looks like this.